HIV reprograms progenitor cells
نویسندگان
چکیده
منابع مشابه
HIV-1 reprograms the migration of macrophages.
Macrophages are motile leukocytes, targeted by HIV-1, thought to play a critical role in host dissemination of the virus. However, whether infection impacts their migration capacity remains unknown. We show that 2-dimensional migration and the 3-dimensional (3D) amoeboid migration mode of HIV-1-infected human monocyte-derived macrophages were inhibited, whereas the 3D mesenchymal migration was ...
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متن کاملKinetic model of HIV infection including hematopoietic progenitor cells.
Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4⁺ T cells at the beginning of...
متن کاملHIV-1 infection of human brain-derived neural progenitor cells
Background HIV-1 infected adults and children may developed CNS disease, but clinical and pathologic manifestations defer. Microglial cells are productively infected in both, but up to 20% of pediatric sub cortical astrocytes may also contain virus, a finding not reported in adults. to investigate this observation, we examined archival HIV-1 pediatric brain, and tested infection of neural proge...
متن کاملHuman Trophoblast Progenitor Cells Express and Release Angiogenic Factors
Trophoblast stem cells develop from polar trophoectoderm and give rise to the cells that generate the placenta. Trophoblast cells are responsible for the uterinal invasion and vascular remodeling during the implantation of the embryo. However this knowledge is not yet to be confirmed for trophoblast progenitor cells (TPCs). In this study, we aimed to demonstrate that human TPCs (hTPCs) express ...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.356.6342.1041-b